The spread of tumours — metastasis — to other sites in the body is the leading cause of death for cancer patients. Up to 90 per cent of cancer deaths are due to this, however the process that regulates the spread of tumours is very poorly understood.
To find out what genes in the body could influence metastasis, the researchers looked at how tumours spread in genetically engineered mice that were missing specific single genes. They screened 810 unique genes and identified 23 genes that either increased or decreased the spread of skin tumour cells to the lungs. Many of these genes also caused an alteration in the immune system, such as changing the bodies’ ability to fight infection.
Removal of the Spns2 gene caused the largest change, reducing spread of tumours to the lungs by approximately four times. The researchers then looked at the effect of this gene on the spread of other cancers, from colon, lung and breast, and showed that taking out Spns2 also reduced the metastasis of these cancers.
Dr David Adams from the Wellcome Trust Sanger Institute, said: “Loss of the Spns2 gene causes the greatest reduction in the formation of tumour colonies and represents a novel therapeutic target. We found that mice lacking Spns2 have a different ratio of immune system cells than normal, which seems to prime the immune system to remove cancer. Drugs that target this could help reduce or prevent the spread of tumours through the body.”
Before this study, the Spns2 gene was known to affect the immune system, but was not implicated in tumour spread. It codes for a protein that transports a lipid, S1P, which signals to the immune system. Without this transporter protein, the signaling doesn’t work properly and results in changes in the proportion of different immune cells in the body.
Dr Anneliese Speak from the Sanger Institute, said: “This work supports the emerging area of immunotherapy, where the bodies’ own immune system is harnessed to fight cancer. Drugs could be designed to bind to the S1P transporter, preventing it from working and causing advantageous changes to the immune system. Investigation of further targets in the Spns2 pathway, or other targets identified in this study could help develop potential therapies.”
Dr Justine Alford, Cancer Research UK’s senior science information officer, said: “This study in mice gives a new insight into the genes that play a role in cancer spreading and may highlight a potential way to treat cancer in the future. Cancer that has spread is tough to treat, so research such as this is vital in the search for ways to tackle this process.”
It’s long been observed that mothers tend to cradle their infants on their left side, and this has long been at least informally attributed to handedness (so that right-handed mothers have the right hand free).
Now researchers report in the journal Nature Ecology & Evolution that “positional bias” is in fact observed in multiple mammal species, and they say the reason for it is likely neurological, as the BBC reports.
Turns out that this positioning on the left activates the brain’s right hemisphere, responsible for processing social activities like communication and bonding. “We suggest that this bias is even more widespread and may be a characteristic of all mammals, with few exceptions,” one researcher says.
Studying wild animals—including horses, walruses, reindeer, sheep, and kangaroos—the team found that young animals tend to keep their mothers on their left and watch her with mainly their left eye.
In dangerous situations, however, the mothers would swap spots to keep their young on their left for better monitoring, reports New Scientist. The scientists recorded nearly 11,000 position choices across 175 pairs of infants and mothers.
That the positional bias is so widespread among mammals suggests, as one researcher put it, that the mechanism is “ancient and really basic.” Meanwhile, the Orange County Register reports on a thrilling drone sighting of a mother and calf whale migrating south—with predictable positioning.
Many breastfed infants may not get enough vitamin D because their mothers prefer not to give babies supplement drops, a study suggests.
Pediatricians recommend that mothers exclusively breastfeed infants until at least six months of age because it can reduce babies’ risk of ear and respiratory infections, sudden infant death syndrome, allergies, childhood obesity and diabetes.
Because breast milk typically doesn’t contain enough vitamin D to help infants develop healthy bones, the American Academy of Pediatrics advises nursing mothers to give their babies daily supplements of 400 IU (international units) of vitamin D. As an alternative, women can take vitamin D supplements themselves – typically 4,000 to 6,000 IU daily – to give babies enough in breast milk so that drops aren’t needed.
The research team surveyed 184 breastfeeding mothers, including 44 mothers who also gave their babies formula in addition to breast milk.
Altogether, just 55 percent of the women said they gave their babies vitamin D drops and only 42 percent supplemented with the recommended 400 IU.
“Many mothers were not aware of the need for vitamin D supplementation or their physician had not recommended supplementation,” said senior study author Dr. Tom Thacher, a researcher at the Mayo Clinic in Rochester, Minnesota.
“Others believed that breast milk had all the needed nutrition, and some mentioned the inconvenience of giving a supplement or their poor experience of giving a supplement to previous children,” Thacher added by email.
Severe vitamin D deficiency can lead to rickets, or soft bones, seizures due to low calcium or heart failure in infants. While adults may get some vitamin D from sunlight, direct sun exposure isn’t recommended for babies.
About 76 percent of mothers said they took vitamin D themselves, and most of them preferred daily supplements to longer-acting versions taken less often. Overall, nearly nine in 10 women said they would prefer to take supplements themselves rather than give drops to their babies.
Women who didn’t give babies vitamin D most often cited safety concerns, the survey found.
Techniques of Weight Loss
Health is regarded as the normal functioning of the body. We always find it easy to do our daily works when our body is healthy. Expect everyone to put health as priority number one in their life. There some factors that can make the body to be unhealthy. Diseases can make our bodies to be unhealthy. There are three categories of infections that can attack our body. We have bacterial, fungal, and viral infections. Maladies lower the immunity of the body. It is possible to cure infections by use of drugs such as antibiotics. Physical injuries can make our bodies to be ill. A physical injury damages the muscles, joints, and tendons of the body. This makes it hard for the body to function properly. Our body can be unhealthy due to sedentary lifestyle. Sedentary lifestyle is a type of life that entails little or no movement. It is likely for a sedentary lifestyle to lead to obesity. Obesity results into an accumulation of calorie on the body. Obesity makes someone to be overweight. Expect obesity also to cause cardiovascular diseases such as heart attacks and strokes.
There are few techniques we can employ to reduce the weight of the body. Exercise can serve as a weight reduction method. We have jogging, spinning, and lifting weights as examples of forms exercises. Expect to find every form of exercises in places such as gymnasiums. It is expected of individuals to register for the various activities at the gym to cure their condition. The work of exercises is to stimulate the structures of the body such as muscles, ligaments, tendons, and joints. This burns the fat found in the muscles thus lowering the weight of the body. Exercises also make the body to be flexible and strong. Exercise machines have been produced as a result of technology. These machines can be found at homes, gym, and therapy sessions. We can lose our weight fast by checking on diet. It should be our aim to stop utilizing foods with excess calories such as meat and eggs.
We should also refrain from taking processed foods such as cooking oils. It is possible to lower the weight of the body by change of eating habits. Bad eating habits should be stopped. We can lower the weight of the body by taking much water in the course of the day. It is recommendable to drink eight glasses of water daily. Water helps in burning extra fat in the body by increasing the rate of metabolism. Weight loss tablets can also help in lowering the weight of the body. Appetite is reduced by using weight loss pills.
How to Find a Sanitation Consultant
Sanitation is very important to all of us. Without it, we will surely get illnesses. Even if we are familiar with simple hand washing, it is still good if you know how to do sanitation properly. And the most ideal way to know about it is to consult with a sanitation consultation. This is because they are very much knowledgeable as well as trained about it. You can easily find a reliable sanitation consultant. Read the given tips below so that you will be able to find the most reliable one. They can be of great help in finding for the best sanitation consultant.
The first thing that you need to do is to search online. You can find almost anything in the web. Once you search in the search engine, you can surely get info including ‘sanitation consultant. The ideal sanitation consultant definitely own an excellent site so to present what they can offer. It is complete vitally important to choose a website that has a lot of information, like for example: contact numbers, email address, business address and so much more. Moreover, see to it that your chosen website will provide easy to use website, photos or even links of their successful work and then customer’s page. The client’s page will allow you to check if such sanitation consultant has a lot of happy clients in the past. Always remember to choose a website that has numerous positive feedback or perhaps reviews from previous clients. In case you read a lot of positive comments or reviews, this only means that the consultant is a very good one.
Another excellent way to find a reliable sanitation consultant is to ask recommendations from loved ones as well as friends. You will able to trust them as they also want you to consult from the best sanitation consultant just like them. Just remember to contact immediately whoever sanitation consultant that is recommended by the majority. Inquire about what type of consultation they can offer, the payment and many more. You must be well-informed about everything before you hire that particular consultant. As an excellent sanitation consultant, they will make you well-informed about their services in order for you to know everything you needed to know about them.
In order for you to effectively find the best sanitation consultant, it is very essential that you follow all the tips written above. Searching for the ideal sanitation consultant is very simple most especially if you will apply the tips given. With the help of these particular consultants, people will surely know proper sanitation. Thus, hiring the best one is really necessary.
How To Feel Better When Getting A Massage
Getting a proper massage is important so that we would be able to fully appreciate the benefits and effects that it is going to have on our body. When getting a massage, make sure that you are able to get your massage from a professional so that you would be able to know that your masseuse is knowledgeable and properly trained on what they are doing. There are a lot of different kinds of massage that you are able to get and it is important that you should make sure that you are able to have a great time, it is important that you should be able to know what you want for your massage so that you would be able to have the masseuse or therapist perform or apply it on your body. In getting a massage you should know that you would be able to demand a good service and if the masseuse or therapist would fail to make you feel comfortable then you would have the right to have the session ended. It is important that you should be able to have your expectations fulfilled when getting a massaged, you should make sure that you can relax and feel good or else you would be able to have your masseuse or therapist changed if they are not good enough.
It is important that you should make sure that you would be able to have a pleasant experience when getting the massage, you should make sure to check on the facilities that they would have to see if they are clean and if it would feel therapeutic and relaxing. You should also ask customers and previews clients about the quality of services that the massage establishment would be able to provide so that you would be able to know if they are able to satisfy your needs or not. It is important that you should take your time in filling up the paperwork that would be given to you in a massage facility as it is something that would determine the condition that you are in and it would also need for you to provide some information about yourself. The type of clothing that you would wear when getting a massage would depend to you and you should know that massage facilities would be able to provide a comfortable set of clothing that would be suited for your massage.
Ways On How to Deal With Jet Lags
It is when you travel by air that you will find it fun and be tiring at the same time. It is jet lag that most people will feel after a long flight. The moment that your body will adjust to the new time zone, then that to the time that you will feel a jet lag. This is because the new time zone is new to your body and is something that it has to adjust to. It is by having a huge jet lag that you will not find it fun especially when you are on a vacation. It is in this article that we will be talking about the different things that you should do is that you will be able to prevent a jet lag.
The very first thing that you can do so that you will be able to prevent a jet lag is to drink a lot of water and avoid caffeine and alcohol while on the flight. Make it a point that you will be avoiding any caffeine or alcoholic beverages even though they are being offered during the flight. It is because it is these components that will cause dehydration to your body. Coupled with the dry air that you have in the plane, the effects will be doubled. It is when your body will be dehydrated that you will feel the worst jet lag ever. It is by drinking a lot of water that you will be able to prevent dehydration to your body.
The next thing that you have to do in order to prevent a jet lag is to have enough sleep on the plane. By the time that you will arrive at your new destination, your body will not have a hard time adjusting to the new time zone the moment that you will give it ample time to rest. You will also be able to get various sleeping aides if you will have hard time falling asleep. But it is still better to ask your physician before you will be talking one of these sleeping aids. Sleeping on the flight is one of the easiest tricks that you can do to prevent jet lags.
To make sure that you will be able to prevent jet lags, it is better not to sleep right away the moment that you will arrive at your destination. The worst jet lag can be experienced by you during the first two days of your arrival to your destination. It is during the odd times of the day that you will be feeling tired. Feeling tired happens usually in the late morning or the late afternoon. Make sure that you will not be sleeping during these times. The right time to sleep is during the night time that is why you have to make sure that you will push yourself to reach that time.
The Wonderful Benefits of Health Insurance If you know about life in general, you might know that it is very unpredictable, and you will never know what is coming in the future until it comes, giving you surprise when the situations you face were things you never expected. Although you cannot prevent or even predict these situations, it is very important that you take steps to prepare for them, as when you do so, you can be sure that you will be able to deal with them in a fitting manner. One will be glad to know that he or she can do this through many methods, one of which includes getting health insurance. Getting health insurance, then, is definitely something that you should do, as it is something that will provide you with so many benefits you enjoy, benefits which you will find are very satisfying and wonderful, especially in the long run, when you face situations that you might not have expected. Getting health insurance is definitely something which is beneficial to you in a lot of different and wonderful ways, one of which is the fact that when you do so, you can be sure to enjoy many kinds of health services for free. The best companies that offer health insurance offer the free coverage of such services like preventive care, which is very important for people to receive, as it gives them the chance to avoid deadly diseases or to discover them when they are in their first stages. One who undergoes preventive health care will definitely be able to benefit because he or she can enjoy the peace of mind which comes through knowing that health is being taken care of in the best way possible. Another thing that people can enjoy through health insurance is the benefit of getting to save a great deal of money. One who needs to take medication regularly might certainly need to spend a great deal of money, as many pharmacies sell these drugs at very high prices. The great news is that those who have health insurance can enjoy huge discounts on medication and other services, which gives them the chance to obtain these things more easily.
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Last but not least, people will benefit when they get health insurance because when they do so, they can prepare for accidents and unexpected events in the best way. These things have a very unpredictable nature, meaning that being well-prepared for them is a step that will make them easier to deal with.
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One who gets health insurance, then, is certainly making a very good decision, as it is one that will lead to the enjoyment of benefits and advantages which are certainly very satisfying and worthwhile.
Home Gym Equipment for Your Regular Workouts
Somehow paying a monthly fee for using your local gym equipment can disrupt your finances. If you want to continue your workouts without having this burden, you should consider investing in a few items of home gym fitness equipment. There will be great savings on your part since you will no longer be paying this monthly fee. And since the equipment is just in your home, you will be encouraged to work out regularly.
Today, you can see many fitness bugs who have invested on workout equipment in their own homes. Most of thee people do not have enough time or money to go regularly to the gym. A lot of people have little time to spare after work. And there are those who don’t want to pay the monthly fee since is just seems like another monthly bill to pay. If you can spend so much on gym membership a year, you could use this money to set up your own workout equipment and save money over time.
There are gym equipment that are very common. The treadmill and the exercise bike are the two most common home gym equipment. It seems that most people have at least one of these in their homes because they are easy to use and do not take up a lot of space. They also give you a solid workout and help your cardiovascular health as well. Treadmills and exercise bikes are sold in stores that sell exercise equipment. You can go to fitness equipment stores, department stores, and online retailers. Choose a model that you like. It would not be difficult to find one.
Workout equipment sets are also very common. These are very popular to fitness enthusiasts and people who like to have an easy workout activity. If you want to get the most out of your workouts and if you have a small space, these workout equipment sets are a good investment although they are more costly than the standard equipment. You get a total body workout from these machines and they do it in a short amount of time than any other type of exercise equipment.
Actually, any type of home gym equipment is a good investment for that matter. If you don’t want to go to a gym but need the regular exercise, then home gym fitness equipment is for you. You can save hundreds of dollars by having your own workout equipment. You don’t even have to leave the comforts of your own home.
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Ways To Buy The Best Home Workout Equipment.
Many people tend to have a gym membership but the problem is always based on how to get there in this case. This could be because of their busy schedules or even by the fact that the gym is quite far from them. That is why many have opted to have a gym in their homes to help them in keeping fit.
There is so much motivation that is seen when one is just moving around the house and seeing equipment lying around in this case. Consider the level of convenience that comes with the home gym in that it is always at your good reach in this case. Then again for those who do not want to spend so much paying for the gym membership then certainly this is the way to go. It will be important for you to know the kind of equipment that you will be working with in this case.
It will be necessary to consider a number of the given factors here when it comes to buying a home workout equipment. Consider a case where the amount of space given will be able to well fit the equipment as required. You will need to avoid the thought of using the bigger equipment in case that you have the dumbbells. In many cases the much space needed is for one to comfortably stand, squat and lay down.
Consider using the equipment right for the purpose it has been set for in this case. Do not buy an equipment and just let it sit there collecting all the dirt possible with no one using it. You have to ensure that you go for the equipment that you can comfortably use in the house. It will be important to consider a case where the equipment will not necessarily need a lot of space to have them stand in this case.
Then definitely the much you will be willing to spend in the process has to be considered. Consider looking at the workout space which will be either a basement or even a garage if you have it in this case. It will be important to consider the much that you have kept aside for the whole activity. Keep in mind that the workout equipment tend to cost much in this case. You have to make sure that what you buy then you will certainly be able to use it to avoid going into major loses.
Factors To Consider When Looking For A Good Home Exercise Equipment.
there are many benefits of working out from your own home rather than joining a gym. One of the benefits of working out is that you will feel better both mentally and emotionally. Thus, in order to make sure that your exercise efforts are successfully, you should purchase the best equipment.
That means that you should first determine your goals. Each individual has varied objectives such as strength building or any other goal. That means that the kind of machine that you choose should be related to your goals. Hence, you should try to learn more about various equipment as well as their features and also uses.
That is because there are some equipment that requires a lot of space while others require less space. Therefore, ensure that you consider all the important elements so that you can have a good shopping experience. In addition, there are some equipment that can be folded and placed in the closet that is in case you have a small house.
If you fail to do your research then there are chances that you will regret the decision that you will make and hence you will only waste your money. Therefore, ensure that you pick the size of the equipment according to the size of your house.
The other critical consideration is the amount of money that you are willing to spend. While there are many people that do not like to conduct a research process, it is very important since it will save your time as well as money. It is important to find out the price of various types of equipment in advance so that you can make the necessary arrangements. That means that you should set aside some time for the research process.
While choosing the least expensive equipment might seem like saving money, but in reality that is not the case as the equipment might not last long and hence you will be required to buy another one. What is more, you can try to find a good equipment online. Internet shopping is very convenient as you will make your orders at your most convenient period. Also, you can easily make your shopping in the middle of the night. Also, you will take less time to do your shopping. The online stores will deliver the item at your doorstep, and thus you will not have to worry about transporting it. You can exercise at any time that you want.
Choosing a Good MMA Training Gym in San Diego In today’s world, nothing is more exciting than athletic competition. Sports serve as social events, and they also allow us to exercise. Keep in mind that there are any number of sports to choose from. Some people like to play football, but others will be more interested in football. If you’re looking for a more intense sport, though, you may want to train for mixed martial arts. In recent years, MMA has really exploded in terms of popularity. At the same time, though, training for MMA isn’t easy. It requires a level of patience and discipline that most people simply do not have. The first step in this process is to find a gym. Fortunately, there are many good MMA gyms in San Diego. If you’re going to be choosing a gym, it’s important for you to define your own expectations. As long as you know what to expect, it should be fairly easy for you to find a gym that meets your needs. Be aware that price is very important here. It’s worth stating that a good San Diego gym does not need to cost a great amount of money. By doing your research, you can find a San Diego MMA gym that fits within your price range.
The Key Elements of Great Services
If you’re going to be training for MMA, it’s important to consider your diet. You will struggle to fight effectively if you are not in good shape. Ideally, you will want to reduce the percentage that fat makes up in your body. You’ll want to reduce your sugar intake, but you should also eat more vegetables. If you’re holding on to too much weight, your stamina will actually decrease. After you have improved your fitness level, you can start looking for a San Diego MMA gym.
Discovering The Truth About Gyms
It’s important for you to prepare if you expect to be an MMA fighter. As you are no doubt aware, mixed martial arts can be truly competitive. You’ll need to train holistically if you want to improve. To get started, think about your own profile. Keep in mind that there are dozens of different ways to fight. As a general rule of thumb, an MMA fighter will fall into one of two categories. Some people will be grapplers, while others will be strikers. The idea here is to play to your strengths. If you’re quick with your hands, striking is a great option. If you understand leverage, though, you will want to focus on grappling. Remember that if you want to become a great fighter, you owe it to yourself to join an MMA gym in San Diego.
Why it is Beneficial to Stop Excessive Sweating Through Iontophoresis. .One might know that sweating is a very normal function of the body, and people sweat in order for their bodies to cool down and to prevent overheating. However, one might notice that he or she sweats more than the normal person, and understand that this condition is one which is known as hyperhidrosis. One will be glad to know that he or she does not need to live with this condition for the rest of his or her life, as there is a way to get rid of it, and this is through a process in which an Iontophoresis machine is used. Purchasing and using this kind of machine from a good company, then, is certainly something that you should do, as it is something which will provide you with many wonderful advantages and benefits to enjoy. Purchasing and starting to use a machine which is designed for Iontophoresis will certainly be wonderfully beneficial to you in so many different ways, one of which is the fact that when you do so, you can be sure to stop the sweating which has become excessive. One who sweats excessively might find himself or herself suffering some disadvantages, some of which include the fact that his or her clothes always end up wet, and the fact that sweating too much can be embarrassing. One will be glad to know, then, that when he or she consistently uses a machine used for Iontophoresis, the problem can slowly but surely be gotten rid of, giving him or her the chance for greater self-confidence and self-assurance. Purchasing a machine used for Iontophoresis is also something which will benefit you in a wonderful way because when you do so, you can be sure that, through this machine, you will be able to enjoy ease of usage. The process of Iontophoresis includes the procedure of small electrical shocks being sent through water towards the skin which, in the long run, will reverse the problem of excessive sweating. One will be glad to know that when he or she purchases a machine used for Iontophoresis, it will be user-friendly and easy to use, meaning that he or she will have an easy time getting rid of a tough problem.
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Last but not least, people who find a good company that offers machines used for Iontophoresis will be able to benefit because when they do so, they can be sure that the machines they buy will be very durable. You will also be glad to know that you can get a good warranty when you make this purchase from a good company, which means that you will definitely be able to enjoy great assurance through it.
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Purchasing a machine designed for Iontophoresis, then, will certainly be beneficial in a lot of different ways, one of which is the fact that when you do so, you can be sure that you will be able to gain the benefits of stopping your excessive sweating, of being able to have a machine which is very easy to use, and to use it for a long time to come because of its durability.