The spread of tumours — metastasis — to other sites in the body is the leading cause of death for cancer patients. Up to 90 per cent of cancer deaths are due to this, however the process that regulates the spread of tumours is very poorly understood.
To find out what genes in the body could influence metastasis, the researchers looked at how tumours spread in genetically engineered mice that were missing specific single genes. They screened 810 unique genes and identified 23 genes that either increased or decreased the spread of skin tumour cells to the lungs. Many of these genes also caused an alteration in the immune system, such as changing the bodies’ ability to fight infection.
Removal of the Spns2 gene caused the largest change, reducing spread of tumours to the lungs by approximately four times. The researchers then looked at the effect of this gene on the spread of other cancers, from colon, lung and breast, and showed that taking out Spns2 also reduced the metastasis of these cancers.
Dr David Adams from the Wellcome Trust Sanger Institute, said: “Loss of the Spns2 gene causes the greatest reduction in the formation of tumour colonies and represents a novel therapeutic target. We found that mice lacking Spns2 have a different ratio of immune system cells than normal, which seems to prime the immune system to remove cancer. Drugs that target this could help reduce or prevent the spread of tumours through the body.”
Before this study, the Spns2 gene was known to affect the immune system, but was not implicated in tumour spread. It codes for a protein that transports a lipid, S1P, which signals to the immune system. Without this transporter protein, the signaling doesn’t work properly and results in changes in the proportion of different immune cells in the body.
Dr Anneliese Speak from the Sanger Institute, said: “This work supports the emerging area of immunotherapy, where the bodies’ own immune system is harnessed to fight cancer. Drugs could be designed to bind to the S1P transporter, preventing it from working and causing advantageous changes to the immune system. Investigation of further targets in the Spns2 pathway, or other targets identified in this study could help develop potential therapies.”
Dr Justine Alford, Cancer Research UK’s senior science information officer, said: “This study in mice gives a new insight into the genes that play a role in cancer spreading and may highlight a potential way to treat cancer in the future. Cancer that has spread is tough to treat, so research such as this is vital in the search for ways to tackle this process.”
It’s long been observed that mothers tend to cradle their infants on their left side, and this has long been at least informally attributed to handedness (so that right-handed mothers have the right hand free).
Now researchers report in the journal Nature Ecology & Evolution that “positional bias” is in fact observed in multiple mammal species, and they say the reason for it is likely neurological, as the BBC reports.
Turns out that this positioning on the left activates the brain’s right hemisphere, responsible for processing social activities like communication and bonding. “We suggest that this bias is even more widespread and may be a characteristic of all mammals, with few exceptions,” one researcher says.
Studying wild animals—including horses, walruses, reindeer, sheep, and kangaroos—the team found that young animals tend to keep their mothers on their left and watch her with mainly their left eye.
In dangerous situations, however, the mothers would swap spots to keep their young on their left for better monitoring, reports New Scientist. The scientists recorded nearly 11,000 position choices across 175 pairs of infants and mothers.
That the positional bias is so widespread among mammals suggests, as one researcher put it, that the mechanism is “ancient and really basic.” Meanwhile, the Orange County Register reports on a thrilling drone sighting of a mother and calf whale migrating south—with predictable positioning.
Many breastfed infants may not get enough vitamin D because their mothers prefer not to give babies supplement drops, a study suggests.
Pediatricians recommend that mothers exclusively breastfeed infants until at least six months of age because it can reduce babies’ risk of ear and respiratory infections, sudden infant death syndrome, allergies, childhood obesity and diabetes.
Because breast milk typically doesn’t contain enough vitamin D to help infants develop healthy bones, the American Academy of Pediatrics advises nursing mothers to give their babies daily supplements of 400 IU (international units) of vitamin D. As an alternative, women can take vitamin D supplements themselves – typically 4,000 to 6,000 IU daily – to give babies enough in breast milk so that drops aren’t needed.
The research team surveyed 184 breastfeeding mothers, including 44 mothers who also gave their babies formula in addition to breast milk.
Altogether, just 55 percent of the women said they gave their babies vitamin D drops and only 42 percent supplemented with the recommended 400 IU.
“Many mothers were not aware of the need for vitamin D supplementation or their physician had not recommended supplementation,” said senior study author Dr. Tom Thacher, a researcher at the Mayo Clinic in Rochester, Minnesota.
“Others believed that breast milk had all the needed nutrition, and some mentioned the inconvenience of giving a supplement or their poor experience of giving a supplement to previous children,” Thacher added by email.
Severe vitamin D deficiency can lead to rickets, or soft bones, seizures due to low calcium or heart failure in infants. While adults may get some vitamin D from sunlight, direct sun exposure isn’t recommended for babies.
About 76 percent of mothers said they took vitamin D themselves, and most of them preferred daily supplements to longer-acting versions taken less often. Overall, nearly nine in 10 women said they would prefer to take supplements themselves rather than give drops to their babies.
Women who didn’t give babies vitamin D most often cited safety concerns, the survey found.
Some Things You Should Know About Online Loans
It is a fact that the internet has been used for various purposes on a worldwide scale. Indeed, the internet is a great source for limitless information regarding any subject. It just takes a bit of browsing from one website to another for you to be able to be equipped with the right knowledge regarding any topic that you want to know. Do you have any idea that you can also avail of loans online? Yes, this is actually a fact, and they are termed online loans.
Online loans can be availed by any person if they choose to apply for one using their computer. With the people’s constant demand for convenience, it does not come as a surprise why technology is headed to this direction. So if you are tired of processing your loan applications traveling from one place to another, your most convenient choice would be online loans.
With the help of the internet, you can immediately check for websites online that offer online loans for quick cash. There is no more need for you to meet each online instant cash loans lender that you see. Such online loan lenders have websites that can accommodate any client every single minute of the day. These websites also provide clients and visitors a way for them to be able to calculate their credit scores for a nominal charge or even for free.
In the previous years, only a few loan lenders provided their clients with several loan choices. For a person to find the most ideal loan lender, he or she should locate each lender and meet up with them personally so that they get an idea of what their available loan options are.
Nowadays, thanks to the internet, you get access to numbers of online lenders, you are guaranteed to find one that offers the best loan option suitable to your needs and preferences. Whether it be secured or unsecured, you can now apply for online personal loans. Moreover, you can choose to remortgage or mortgage your property. Getting quick cash gets more easier with this. You can even quickly make use of this cash for whatever purpose you have. Repayment of the loan amount and monthly payments are what really matters when it comes to the online loan lender.
Online loan calculators are also being offered to clients by some online loan lenders out there. Using this calculator allows one to evaluate the term that the loan will be granted as well as the monthly payments. It is also highly advised that loan quotes will be obtained from a number of online loan lenders. By doing this, loan quotes are easily compared from different online loan lenders so that you will be able to assess more appropriately which one suits you best.
Reasons to Choose Online Business Loans
Now that you are ready to start your own business that requires some funding, there is no need to limit your options to traditional banks. Whether it is a short term loan or an installment loan you need, there are loans you can apply over the Internet which are known as online loans.
Borrowers from ten years ago would not find online business loans a viable alternative for their needs. Instead, conventional banks were the norm when small business owners were in need of funding. Fast forward to today and commercial banks still lead the way when it comes to providing credit even though regular banks loans are very challenging to secure.
There are reasons why commercial banks tighten access to credit for small businesses. Rightly or wrongly, they still think lending to small businesses is a risky proposition. In addition, the process of lending to small businesses is as exhaustive as that of bigger businesses but with a smaller payoff. Nowadays, only a limited number of small businesses are approved for bank loans.
This is where online business loans can be helpful. Online lenders are in the lending marketplace to serve small enterprises that were not approved for bank credit. In case your bank loan application for your startup business was declined , you may want to look at an online loan. So what makes an online business loan different from a bank loan?
Anyone who has tried processing an application for a regular bank loan knows that it can take days before the results are known. Try applying to an online lender and you will notice the difference in how much faster the process is done.
The reason for this is that online business lenders are not banking institutions that have to comply with a number of government regulations that slow down the loan approval process. No government red tape means no paperwork. There is no need to look for and gather documents as the lender won’t require them in order to process your application. And because it is done online, the processing of your small business loan application will be considerably quicker.
Regular banks tend to offer term loans, credit cards, lines of credit and other traditional business loans. Online business loans, on the other hand, afford you some flexibility when it comes to choosing the loan product that will suit your need. You do not have to limit yourself to the usual loans. Depending on your purpose, there is an online business loan that corresponds to your needs.
In addition, online business loans come in varying amounts subject to how much you need for your small business. If a bank won’t consider processing loans for less than R250,000, online lenders will do it for you from R5,000 to R250,000.
FOR IMMEDIATE RELEASE
VAIL, Colo. — With a name that translates as “tomorrow’s leaf,” the ashitaba plant of Japan’s southern islands is remarkable in its own right. After a leaf has been harvested in the morning, it will often be replaced overnight, making for an impressive spectacle of natural regeneration. People living in the ashitaba plant’s native range have long appreciated it for many other reasons, too, using it regularly in everything from noodles, tea, and ice cream to traditional medicine.
Thanks to a new special offer at experiencing everything ashitaba has to offer has never been more affordable. For a limited time, Kenko shoppers can purchase top-quality, carefully harvested ashitaba tea at a discount of more than one-third off the regular price. The kenko.green website also includes educational resources that can help visitors learn more about the ashitaba plant’s history, significance, and appeal.
“Ashitaba is considered by many one of the natural world’s best-kept secrets, but awareness about the plant is building rapidly worldwide,” said Kenko representative Nick Eberle, “Packed with almost twice the antioxidants of green tea and lots of health-promoting minerals, ashitaba truly deserves the attention it is receiving. We’re proud to offer our customers access to the best ceremonial grade of ashitaba tea. We work directly with Japanese farmers who have cultivated their land for generations to offer only the finest tea under the Kenko Ashitaba label. Thanks to our new, ongoing sale, it has never been easier or more affordable to stock up on ashitaba tea or try it for the first time.”
Japan comprises more than 6,000 islands, of which only around 400 are currently inhabited. The four largest Japanese islands combined host the vast majority of the country’s population and land mass, but many of the smaller ones have their own distinct cultures, histories, and traditions. With a population of around 10,000 and an area of about 25 square miles, the small southern island of Hachijo-jima is the natural home of the Angelica keiskei Koidzumi plant, known in Japanese as “ashitaba.”
For centuries, people living on Hachijo-jima and in other places where it has since been spread and cultivated have made ashitaba a central part of everyday life. The hardy, fast-growing plant has also begun to attract a great deal of attention around the world, with antioxidant levels nearly twice those typical of green tea, for example, leading many to explore what the plant has to offer.
Kenko is a well-known source for the highest grade of ashitaba tea. Focusing solely on delivering ashitaba of the best possible quality to customers, the company works with carefully selected farmers whose respect and consideration for their land helps the plant achieve its potential with every harvest. Low-temperature processing and careful handling thereafter ensure that Kenko clients always receive ashitaba tea of the highest quality. With a special, limited-time sale now ongoing at this peerless grade of ashitaba tea has never been more affordable.
Offering only the best ashitaba tea to customers, Kenko works with carefully selected local farmers to ensure the highest quality with every purchase.
Finding the Right Personal Trainer Those days when personal trainers were only for the rich and famous are gone. If you don’t have the motivation to work out on your own, enjoy variety but have no idea how to create your own program, or you have very specific goals for training, you can benefit from hiring a personal trainer. But how are you to choose one, considering there are almost countless fitness pros today? What to Look For What to Look For Among the most important things to look into is the trainer’s credentials. You want to hire someone who has a reputable certification and a degree in exercise and fitness preferably. Three examples of reputable certification bodies offering an online search utility that you can using when looking for local trainers are the IDEA Health and Fitness Association, the National Strength & Conditioning Association and the American Council on Exercise.
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Other good certifications that have no web search tools are the American College of Sports Medicine and the Aerobics & Fitness Association of America. These sites are helpful in general because they come with information regarding the trainer’s qualifications, which are certainly important when you’re trying to decide whom to hire. Besides fitness/exercise certification and formal education, you should also work with a trainer who has current certification in CPR and First Aid .
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Interviewing a Trainer Remember that this trainer is going to work for you. Therefore, treat your initial meeting as a job interview, during which you must ask the following questions: > What are your credentials, and how many years have you been working as a personal trainer? > What are the motivational techniques you often use on your clients so they can reach their goals? > After learning about my specific fitness goals, what type of workout plan will you create for me? > Can you give me a few client references whom I can call? > What are your available hours? If a trainer isn’t happy about the schedule that works for you, then it’s obvious you have to find someone else. > What fitness assessments (strength and stability, body fat testing, etc.) do you usually perform, and how often do you do them? > What are your cancellation rules? Typically, you need to tell your trainer 24-48 hours ahead of the session you intend to cancel so you won’t be charged for it.
Reasons Why You Should Buy Your Wonder Core Smart Through The Internet. There are many manufacturers that make the wonder core smart, and therefore it is not easy to determine a reliable one. That means that you should try to find a wonder core smart manufacturer that is common because that means that most people understand that he makes superior quality items. A trusted company will definitely offer high quality exercise equipment that you can rely on for many years. That is because there are benefits of selling new as well as advantages of selling old gym equipment and that means that you should determine the one that is appropriate for you. A new gym equipment will last for a long time because no one else has used the equipment. Research on different wonder core smarts that are available in the market and also look at the different pictures that are available in the market. When purchasing wonder core smart, you should ask for assurance of satisfaction when you use the equipment. Also, the company that you pick for your wonder core smart should have an excellent customer service. There are some sellers that do not reply to emails and it is very hard to reach them through the phone. If you feel that your potential seller is not confident in his work, then you should search for another one.
What I Can Teach You About Fitness
In addition, it is hard to determine whether a particular seller is a good choice for you by just looking at him without conducting an investigation. Ensure that you read the comments of the previous clients and determine whether they were happy with the products that they received.
Fitness: 10 Mistakes that Most People Make
Also, you should shop around and determine the quality of the wonder core smart that are found in your neighborhood. Also, ensure that you ask for recommendations from your friends as well as family members. In case you do not find a good wonder core smart at your local store then you should search for one online. There are many benefits of shopping for your wonder core smart online because you will buy it at a lower cost. The physical stores hire employees and also pay rent for their business space and that indicates that they incur high amounts of operation costs. There are very many online companies that means that they are all competing to get the attention of the shoppers. On the other hand, the physical stores sell their products at higher costs because they incur high amounts of overhead expenses since they need to pay rent and also salaries to their workers. That is because it is easy to do your shopping from the comfort of your house without going out.
What is More Effective- Herbal or Prescribed Medicine
In this modern day, the two types of medicines, which are herbal and pharmaceutical, are generally being bought and used in almost anywhere in the world at this moment. There are basically plenty of individuals who would love to argue on claiming that someone of the two is better, which the truth of the matter is that it is actually not yet possible for any person to prove that one side is better than the other. Even though both types of medicinal options may indeed have some clear similarities in terms of effectiveness as a cure or remedy, there are still some distinct differences between the two. Which is why, in this article, we will try to show you the different types of qualities between the two different types of medicines.
One of the differences between pharmaceutical drugs and herbal supplements is their respective prices. It is well known that almost every type of pharmaceutical drugs that you can find in your local pharmacy is priced way more than the herbal supplements. The truth of the matter as to why prescription drugs are majorly expensive most especially in the United States is mainly because of the fact that the government is monopolizing pharmaceuticals and they are also preventing any types of variation of the expensive prescription drugs from coming inside easily to be sold as a generic brand. Therefore, more local individuals who live in the USA would instead take herbal supplements rather than them having to pay ridiculous prices. Another obvious difference between prescribed drugs and herbal medicines is that prescribed drugs are relatively dangerous if used incorrectly.
There are a lot of cases as to where people get bed ridden or hospitalized all over the world due to over dosage of prescribed drugs. The worst part about prescribed drugs is that the also have obvious side effects as well, that can affect our everyday lives and activities negatively. While on the other side of the subject matter is that herbal supplements is popularly known to be highly safe to use and they also do not have any side effects as well.
And finally the last difference between herbal supplement and prescribed drugs is their legitimate proven effectiveness. Although prescribed drugs is indeed known to be highly expensive to purchase, it is still one of the most effective medicinal products there is, which is also proven by most pharmaceutical professionals, while on the other hand herbal medicine’s effectiveness in not yet proven by professionals, although most of their users would argue that they are more effective than prescribed drugs. In conclusion, people just basically want to take medicines that are not expensive, highly safe and also works effectively at the same time, which is what herbal supplements is all about, which is why you should switch to herbal supplements since they are not only safe, cost way less and even works better.
Tips on Getting Better Sleep
There is much discomfort in being unable to sleep. There are those who get restless the entire day due to lack of enough sleep as required. This comes as a result of being human where one is entitled to relaxing the body and mind. It is obvious that every person sleeps. But, the timeframe of taking this rest varies from one individual to another. In case you are experiencing challenges with sleeping, read on for more tips to enhance your rest.
One of the ways to go about it is coming up with a daily timetable. Do not focus on all the activities you plan to execute during the day. Your focus should lie on the sleeping hours as well as those of waking up. This mechanism creates a permanent body clock, which works well in ensuring you get enough sleep.
You have to create a conducive ambient so as to enjoy sleep. Given you disturbed nature, settle for dark rooms with no noise and yet full of comfort. You are also advised to switch off the phone since noises as minor as message alerts can be a cause of disruption. You can go for measures that help in separating you from the real world. On this note, you can go for eye masks and comfortable ear masks.
There are people who have the habit of sleeping during the day, or after working for some hours. This practice can be a cause of lacking sleep during the night. Hence, adjust the number of hours you sleep during the day accordingly to ensure you get some sleep during thee night. You should also know that maximizing your energy will help you sleep better.
The discussed tips are just a few of those that experts advise upon. You can get more content by reading related books, or simply by browsing the internet. Most importantly. However, you require to be consistent and also have a high sense of discipline. The food you consume and the lifestyle you live are some aspects that rotate around discipline. Alcoholic drinks have not been understood under this context. There are those who feel like sleep gets better with the drowsy effect. However, the theory is not true as there are those who find it more disruptive. More to it, these drinks do more harm than good since you wake up with a hangover, which erases the refreshing aspect. You are also requested to avoid all drinks that have caffeine.The fact that it is a stimulant may contribute to your lack of sleep. Waking up to visit the bathroom is another disadvantage of taking drinks before bedtime.
You can also use exercises as a means of solving the sleep issues. But, you will only enjoy the fruits once you do the right exercises, in the right way and at the right time.
Questions to Ask Your Plastic Surgeon It is advisable that you do your homework well before you undergo any plastic surgery. This procedure is very delicate and it should not be taken lightly. Look for the right surgeon, have an overall look at the procedure, overweigh the risks before you decide to undergo the process. You can ask the surgeon these questions before you undergo the procedure. The first and the most important question to ask the surgeon is if they are certified and licensed by the licensing board. For your own sake it is important to ask this question because someone can attend a seminar over the weekend and start claiming they are plastic surgeons. If they are licensed you will be happy to know that they have undergone the right training and education to become plastic surgeons. Also, this will mean that they have undergone for further studies to get re-certified. Ask for their experience in the field because it is important. You will know that the surgeon is an expert if they have been in the field for a long time. You will also be sure that if anything unexpected happens the surgeon will be able to handle the situation It is important to ask the surgeon if they have an accredited and equipped facility in case an emergency occurs. If the surgeon tells you the facility is available you should ensure the facility has the required equipment and staff to carry to handle the emergency. Before undergoing the surgery you should ask the surgeon about the type of equipment and techniques they use to perform the surgery. If you ask this question you will know if the equipment they are using are up to date. If they are using the current equipment you will know that you will receive the most efficient and the most effective surgery. Another question you should ask the doctor is they type of anesthesia they will use. If the local one is going to be used then you should know that there is less risk that will be involved. If your plastic surgery will require any anesthesia you should inform your doctors of any allergies that you might be having.
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It is important that you ask the surgeon is about the risks you are likely to face during and after the procedure. The question gives you a chance to prepare yourself for any possibilities that may occur. This gives you a chance to think about what will happen after the surgery. Ask the plastic surgeon of he can show you photos of procedures he has conducted before and the outcome after the surgery. This will give you an idea of how your outcome will be. If you want to plan your time ask the surgeon about the healing time. Don’t forget to ask in the kind of result you should expect and if they have the aftercare service.Where To Start with Health and More
How To Find A Suitable Fitness Equipment.
You should make sure that you carry out an investigation so that you cannot lose your money by picking an equipment that is of low quality. One of the most important factors to consider is the room that you will place the equipment. There are some fitness tools that take up a lot of space. Also, as you exercise, you will also need space, and that means that the room should be big enough.
In addition, you should do your research and ensure that you know the right features of the fitness equipment that you are interested in. Ensure that you go through the reviews of different fitness equipment and try to read about their benefits. Guarantee that you contemplate about the amount of money that you want to use to shop for your workout equipment. Whereas most essential fitness tools are costly, you should consider it an investment. On the other hand, you should only choose the equipment that you can afford.
That is because there are some types of gym equipment that are cheap while others are costly. You should be careful about the television commercials that inform you about a particular fitness equipment that will offer good and fast outcomes with little effort. Guarantee that you do your research online. That means that when you are well informed then it will be easy to make a good decision that you will not regret. Thus, you need to look at the pictures of various websites and try to best fitness equipment that is available.
There are many reasons why you should buy your fitness equipment online. One of the biggest reasons to shop online is that it is simple and has a variety of options. In addition, you can place orders for your fitness equipment from any location that you want.
Thus, if it is raining, then you will do your shopping from your house comfortably. In addition, you will realize that the costs of the online fitness equipment are very affordable. Internet based companies experience little costs compared to the tradtional shops.
You ought to focus your search to health equipment shops which are offering promotions and discounts on their items so that you can save money. Moreover, you will discover that there are different kinds of fitness equipment that are available on the internet and therefore, you will have an easy time finding the right one for you.
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Pointers for Finding Luxury Vacation Rentals
It is a time you have been waiting for all year: Taking a break from work to enjoy among many luxurious holiday villas for hire you have searched for months-on-end beforehand. After going through lots of prospective luxury vacation properties, you’ve finally gotten to the villa of your choice, also it’s in an invigorating venue. Here, you detect the differences between luxurious accommodations and the trimmings of your house; here, it is possible to relax, unwind, forget your daily problems, and break free from the rut of working for a dwelling. On this note, below are some luxury vacation rental suggestions you may use to make sure your absolute satisfaction from the initial hour of your holiday to the last.
It is possible to use online rental agencies, papers, magazines, real estate agents to assist you find the vacation home of your choice. Furthermore, among the tried and true ways to search for a rental home is through your friends and neighbors. After all, a recommendation from people you trust regarding luxury holiday agencies or rental luxurious holiday villas is the most clear-cut means for you to get reliable outcomes. When it comes to renting villas, Nicaragua, Malta and Cancun are on the list of the most visited venues.
Locate a rental agent, homeowner, or assistant that is worth your time and attention. Research about the gains and drawbacks of prospective villas completely via the Net- after al we are in the Digital Age, so we would as well make the most of it- to be able to compare conveniences check out which luxury getaway rental is the most luxurious one of them all. Additionally, get a rental agreement on paper to guarantee a quality bound handling of your vacation details.
An assistant is the man that takes care of nearly all particulars of your getaway rental vacation such that the remaining portion of the hints below will only enable you to double check particular problems to find out if everything is in order. He is also the person who’ll customize your vacation to your individual tastes, so employ this professional ASAP to avoid any potential strategies nightmares you may have.
Don’t assume something even if you’ve an assistant managing the details and a homeowner ensuring you that all of your worries have been handled. What’s more, even the greeter that welcomes you to the house is specifically there to assist you with anything you would like, so having your questions answered throughout or actually prior to the excursion is a must.
Ask for contact info from your provider of your villa for local emergency numbers for the fire department, police force, as well as a medical facility in case of an emergency.