The spread of tumours — metastasis — to other sites in the body is the leading cause of death for cancer patients. Up to 90 per cent of cancer deaths are due to this, however the process that regulates the spread of tumours is very poorly understood.
To find out what genes in the body could influence metastasis, the researchers looked at how tumours spread in genetically engineered mice that were missing specific single genes. They screened 810 unique genes and identified 23 genes that either increased or decreased the spread of skin tumour cells to the lungs. Many of these genes also caused an alteration in the immune system, such as changing the bodies’ ability to fight infection.
Removal of the Spns2 gene caused the largest change, reducing spread of tumours to the lungs by approximately four times. The researchers then looked at the effect of this gene on the spread of other cancers, from colon, lung and breast, and showed that taking out Spns2 also reduced the metastasis of these cancers.
Dr David Adams from the Wellcome Trust Sanger Institute, said: “Loss of the Spns2 gene causes the greatest reduction in the formation of tumour colonies and represents a novel therapeutic target. We found that mice lacking Spns2 have a different ratio of immune system cells than normal, which seems to prime the immune system to remove cancer. Drugs that target this could help reduce or prevent the spread of tumours through the body.”
Before this study, the Spns2 gene was known to affect the immune system, but was not implicated in tumour spread. It codes for a protein that transports a lipid, S1P, which signals to the immune system. Without this transporter protein, the signaling doesn’t work properly and results in changes in the proportion of different immune cells in the body.
Dr Anneliese Speak from the Sanger Institute, said: “This work supports the emerging area of immunotherapy, where the bodies’ own immune system is harnessed to fight cancer. Drugs could be designed to bind to the S1P transporter, preventing it from working and causing advantageous changes to the immune system. Investigation of further targets in the Spns2 pathway, or other targets identified in this study could help develop potential therapies.”
Dr Justine Alford, Cancer Research UK’s senior science information officer, said: “This study in mice gives a new insight into the genes that play a role in cancer spreading and may highlight a potential way to treat cancer in the future. Cancer that has spread is tough to treat, so research such as this is vital in the search for ways to tackle this process.”
It’s long been observed that mothers tend to cradle their infants on their left side, and this has long been at least informally attributed to handedness (so that right-handed mothers have the right hand free).
Now researchers report in the journal Nature Ecology & Evolution that “positional bias” is in fact observed in multiple mammal species, and they say the reason for it is likely neurological, as the BBC reports.
Turns out that this positioning on the left activates the brain’s right hemisphere, responsible for processing social activities like communication and bonding. “We suggest that this bias is even more widespread and may be a characteristic of all mammals, with few exceptions,” one researcher says.
Studying wild animals—including horses, walruses, reindeer, sheep, and kangaroos—the team found that young animals tend to keep their mothers on their left and watch her with mainly their left eye.
In dangerous situations, however, the mothers would swap spots to keep their young on their left for better monitoring, reports New Scientist. The scientists recorded nearly 11,000 position choices across 175 pairs of infants and mothers.
That the positional bias is so widespread among mammals suggests, as one researcher put it, that the mechanism is “ancient and really basic.” Meanwhile, the Orange County Register reports on a thrilling drone sighting of a mother and calf whale migrating south—with predictable positioning.
Many breastfed infants may not get enough vitamin D because their mothers prefer not to give babies supplement drops, a study suggests.
Pediatricians recommend that mothers exclusively breastfeed infants until at least six months of age because it can reduce babies’ risk of ear and respiratory infections, sudden infant death syndrome, allergies, childhood obesity and diabetes.
Because breast milk typically doesn’t contain enough vitamin D to help infants develop healthy bones, the American Academy of Pediatrics advises nursing mothers to give their babies daily supplements of 400 IU (international units) of vitamin D. As an alternative, women can take vitamin D supplements themselves – typically 4,000 to 6,000 IU daily – to give babies enough in breast milk so that drops aren’t needed.
The research team surveyed 184 breastfeeding mothers, including 44 mothers who also gave their babies formula in addition to breast milk.
Altogether, just 55 percent of the women said they gave their babies vitamin D drops and only 42 percent supplemented with the recommended 400 IU.
“Many mothers were not aware of the need for vitamin D supplementation or their physician had not recommended supplementation,” said senior study author Dr. Tom Thacher, a researcher at the Mayo Clinic in Rochester, Minnesota.
“Others believed that breast milk had all the needed nutrition, and some mentioned the inconvenience of giving a supplement or their poor experience of giving a supplement to previous children,” Thacher added by email.
Severe vitamin D deficiency can lead to rickets, or soft bones, seizures due to low calcium or heart failure in infants. While adults may get some vitamin D from sunlight, direct sun exposure isn’t recommended for babies.
About 76 percent of mothers said they took vitamin D themselves, and most of them preferred daily supplements to longer-acting versions taken less often. Overall, nearly nine in 10 women said they would prefer to take supplements themselves rather than give drops to their babies.
Women who didn’t give babies vitamin D most often cited safety concerns, the survey found.
Ways On How to Deal With Jet Lags
It is when you travel by air that you will find it fun and be tiring at the same time. It is jet lag that most people will feel after a long flight. The moment that your body will adjust to the new time zone, then that to the time that you will feel a jet lag. This is because the new time zone is new to your body and is something that it has to adjust to. It is by having a huge jet lag that you will not find it fun especially when you are on a vacation. It is in this article that we will be talking about the different things that you should do is that you will be able to prevent a jet lag.
The very first thing that you can do so that you will be able to prevent a jet lag is to drink a lot of water and avoid caffeine and alcohol while on the flight. Make it a point that you will be avoiding any caffeine or alcoholic beverages even though they are being offered during the flight. It is because it is these components that will cause dehydration to your body. Coupled with the dry air that you have in the plane, the effects will be doubled. It is when your body will be dehydrated that you will feel the worst jet lag ever. It is by drinking a lot of water that you will be able to prevent dehydration to your body.
The next thing that you have to do in order to prevent a jet lag is to have enough sleep on the plane. By the time that you will arrive at your new destination, your body will not have a hard time adjusting to the new time zone the moment that you will give it ample time to rest. You will also be able to get various sleeping aides if you will have hard time falling asleep. But it is still better to ask your physician before you will be talking one of these sleeping aids. Sleeping on the flight is one of the easiest tricks that you can do to prevent jet lags.
To make sure that you will be able to prevent jet lags, it is better not to sleep right away the moment that you will arrive at your destination. The worst jet lag can be experienced by you during the first two days of your arrival to your destination. It is during the odd times of the day that you will be feeling tired. Feeling tired happens usually in the late morning or the late afternoon. Make sure that you will not be sleeping during these times. The right time to sleep is during the night time that is why you have to make sure that you will push yourself to reach that time.
The Wonderful Benefits of Health Insurance If you know about life in general, you might know that it is very unpredictable, and you will never know what is coming in the future until it comes, giving you surprise when the situations you face were things you never expected. Although you cannot prevent or even predict these situations, it is very important that you take steps to prepare for them, as when you do so, you can be sure that you will be able to deal with them in a fitting manner. One will be glad to know that he or she can do this through many methods, one of which includes getting health insurance. Getting health insurance, then, is definitely something that you should do, as it is something that will provide you with so many benefits you enjoy, benefits which you will find are very satisfying and wonderful, especially in the long run, when you face situations that you might not have expected. Getting health insurance is definitely something which is beneficial to you in a lot of different and wonderful ways, one of which is the fact that when you do so, you can be sure to enjoy many kinds of health services for free. The best companies that offer health insurance offer the free coverage of such services like preventive care, which is very important for people to receive, as it gives them the chance to avoid deadly diseases or to discover them when they are in their first stages. One who undergoes preventive health care will definitely be able to benefit because he or she can enjoy the peace of mind which comes through knowing that health is being taken care of in the best way possible. Another thing that people can enjoy through health insurance is the benefit of getting to save a great deal of money. One who needs to take medication regularly might certainly need to spend a great deal of money, as many pharmacies sell these drugs at very high prices. The great news is that those who have health insurance can enjoy huge discounts on medication and other services, which gives them the chance to obtain these things more easily.
If You Think You Understand Insurance, Then This Might Change Your Mind
Last but not least, people will benefit when they get health insurance because when they do so, they can prepare for accidents and unexpected events in the best way. These things have a very unpredictable nature, meaning that being well-prepared for them is a step that will make them easier to deal with.
Study: My Understanding of Services
One who gets health insurance, then, is certainly making a very good decision, as it is one that will lead to the enjoyment of benefits and advantages which are certainly very satisfying and worthwhile.
Home Gym Equipment for Your Regular Workouts
Somehow paying a monthly fee for using your local gym equipment can disrupt your finances. If you want to continue your workouts without having this burden, you should consider investing in a few items of home gym fitness equipment. There will be great savings on your part since you will no longer be paying this monthly fee. And since the equipment is just in your home, you will be encouraged to work out regularly.
Today, you can see many fitness bugs who have invested on workout equipment in their own homes. Most of thee people do not have enough time or money to go regularly to the gym. A lot of people have little time to spare after work. And there are those who don’t want to pay the monthly fee since is just seems like another monthly bill to pay. If you can spend so much on gym membership a year, you could use this money to set up your own workout equipment and save money over time.
There are gym equipment that are very common. The treadmill and the exercise bike are the two most common home gym equipment. It seems that most people have at least one of these in their homes because they are easy to use and do not take up a lot of space. They also give you a solid workout and help your cardiovascular health as well. Treadmills and exercise bikes are sold in stores that sell exercise equipment. You can go to fitness equipment stores, department stores, and online retailers. Choose a model that you like. It would not be difficult to find one.
Workout equipment sets are also very common. These are very popular to fitness enthusiasts and people who like to have an easy workout activity. If you want to get the most out of your workouts and if you have a small space, these workout equipment sets are a good investment although they are more costly than the standard equipment. You get a total body workout from these machines and they do it in a short amount of time than any other type of exercise equipment.
Actually, any type of home gym equipment is a good investment for that matter. If you don’t want to go to a gym but need the regular exercise, then home gym fitness equipment is for you. You can save hundreds of dollars by having your own workout equipment. You don’t even have to leave the comforts of your own home.
Cited reference: official statement
Ways To Buy The Best Home Workout Equipment.
Many people tend to have a gym membership but the problem is always based on how to get there in this case. This could be because of their busy schedules or even by the fact that the gym is quite far from them. That is why many have opted to have a gym in their homes to help them in keeping fit.
There is so much motivation that is seen when one is just moving around the house and seeing equipment lying around in this case. Consider the level of convenience that comes with the home gym in that it is always at your good reach in this case. Then again for those who do not want to spend so much paying for the gym membership then certainly this is the way to go. It will be important for you to know the kind of equipment that you will be working with in this case.
It will be necessary to consider a number of the given factors here when it comes to buying a home workout equipment. Consider a case where the amount of space given will be able to well fit the equipment as required. You will need to avoid the thought of using the bigger equipment in case that you have the dumbbells. In many cases the much space needed is for one to comfortably stand, squat and lay down.
Consider using the equipment right for the purpose it has been set for in this case. Do not buy an equipment and just let it sit there collecting all the dirt possible with no one using it. You have to ensure that you go for the equipment that you can comfortably use in the house. It will be important to consider a case where the equipment will not necessarily need a lot of space to have them stand in this case.
Then definitely the much you will be willing to spend in the process has to be considered. Consider looking at the workout space which will be either a basement or even a garage if you have it in this case. It will be important to consider the much that you have kept aside for the whole activity. Keep in mind that the workout equipment tend to cost much in this case. You have to make sure that what you buy then you will certainly be able to use it to avoid going into major loses.
Factors To Consider When Looking For A Good Home Exercise Equipment.
there are many benefits of working out from your own home rather than joining a gym. One of the benefits of working out is that you will feel better both mentally and emotionally. Thus, in order to make sure that your exercise efforts are successfully, you should purchase the best equipment.
That means that you should first determine your goals. Each individual has varied objectives such as strength building or any other goal. That means that the kind of machine that you choose should be related to your goals. Hence, you should try to learn more about various equipment as well as their features and also uses.
That is because there are some equipment that requires a lot of space while others require less space. Therefore, ensure that you consider all the important elements so that you can have a good shopping experience. In addition, there are some equipment that can be folded and placed in the closet that is in case you have a small house.
If you fail to do your research then there are chances that you will regret the decision that you will make and hence you will only waste your money. Therefore, ensure that you pick the size of the equipment according to the size of your house.
The other critical consideration is the amount of money that you are willing to spend. While there are many people that do not like to conduct a research process, it is very important since it will save your time as well as money. It is important to find out the price of various types of equipment in advance so that you can make the necessary arrangements. That means that you should set aside some time for the research process.
While choosing the least expensive equipment might seem like saving money, but in reality that is not the case as the equipment might not last long and hence you will be required to buy another one. What is more, you can try to find a good equipment online. Internet shopping is very convenient as you will make your orders at your most convenient period. Also, you can easily make your shopping in the middle of the night. Also, you will take less time to do your shopping. The online stores will deliver the item at your doorstep, and thus you will not have to worry about transporting it. You can exercise at any time that you want.
Choosing a Good MMA Training Gym in San Diego In today’s world, nothing is more exciting than athletic competition. Sports serve as social events, and they also allow us to exercise. Keep in mind that there are any number of sports to choose from. Some people like to play football, but others will be more interested in football. If you’re looking for a more intense sport, though, you may want to train for mixed martial arts. In recent years, MMA has really exploded in terms of popularity. At the same time, though, training for MMA isn’t easy. It requires a level of patience and discipline that most people simply do not have. The first step in this process is to find a gym. Fortunately, there are many good MMA gyms in San Diego. If you’re going to be choosing a gym, it’s important for you to define your own expectations. As long as you know what to expect, it should be fairly easy for you to find a gym that meets your needs. Be aware that price is very important here. It’s worth stating that a good San Diego gym does not need to cost a great amount of money. By doing your research, you can find a San Diego MMA gym that fits within your price range.
The Key Elements of Great Services
If you’re going to be training for MMA, it’s important to consider your diet. You will struggle to fight effectively if you are not in good shape. Ideally, you will want to reduce the percentage that fat makes up in your body. You’ll want to reduce your sugar intake, but you should also eat more vegetables. If you’re holding on to too much weight, your stamina will actually decrease. After you have improved your fitness level, you can start looking for a San Diego MMA gym.
Discovering The Truth About Gyms
It’s important for you to prepare if you expect to be an MMA fighter. As you are no doubt aware, mixed martial arts can be truly competitive. You’ll need to train holistically if you want to improve. To get started, think about your own profile. Keep in mind that there are dozens of different ways to fight. As a general rule of thumb, an MMA fighter will fall into one of two categories. Some people will be grapplers, while others will be strikers. The idea here is to play to your strengths. If you’re quick with your hands, striking is a great option. If you understand leverage, though, you will want to focus on grappling. Remember that if you want to become a great fighter, you owe it to yourself to join an MMA gym in San Diego.
Why it is Beneficial to Stop Excessive Sweating Through Iontophoresis. .One might know that sweating is a very normal function of the body, and people sweat in order for their bodies to cool down and to prevent overheating. However, one might notice that he or she sweats more than the normal person, and understand that this condition is one which is known as hyperhidrosis. One will be glad to know that he or she does not need to live with this condition for the rest of his or her life, as there is a way to get rid of it, and this is through a process in which an Iontophoresis machine is used. Purchasing and using this kind of machine from a good company, then, is certainly something that you should do, as it is something which will provide you with many wonderful advantages and benefits to enjoy. Purchasing and starting to use a machine which is designed for Iontophoresis will certainly be wonderfully beneficial to you in so many different ways, one of which is the fact that when you do so, you can be sure to stop the sweating which has become excessive. One who sweats excessively might find himself or herself suffering some disadvantages, some of which include the fact that his or her clothes always end up wet, and the fact that sweating too much can be embarrassing. One will be glad to know, then, that when he or she consistently uses a machine used for Iontophoresis, the problem can slowly but surely be gotten rid of, giving him or her the chance for greater self-confidence and self-assurance. Purchasing a machine used for Iontophoresis is also something which will benefit you in a wonderful way because when you do so, you can be sure that, through this machine, you will be able to enjoy ease of usage. The process of Iontophoresis includes the procedure of small electrical shocks being sent through water towards the skin which, in the long run, will reverse the problem of excessive sweating. One will be glad to know that when he or she purchases a machine used for Iontophoresis, it will be user-friendly and easy to use, meaning that he or she will have an easy time getting rid of a tough problem.
Overwhelmed by the Complexity of Cures? This May Help
Last but not least, people who find a good company that offers machines used for Iontophoresis will be able to benefit because when they do so, they can be sure that the machines they buy will be very durable. You will also be glad to know that you can get a good warranty when you make this purchase from a good company, which means that you will definitely be able to enjoy great assurance through it.
The Beginner’s Guide to Tips
Purchasing a machine designed for Iontophoresis, then, will certainly be beneficial in a lot of different ways, one of which is the fact that when you do so, you can be sure that you will be able to gain the benefits of stopping your excessive sweating, of being able to have a machine which is very easy to use, and to use it for a long time to come because of its durability.
Advantages Of Hiring A Fitness Coach A wellbeing tutor is a readied calling who prepares, leads and induces individuals in different practice works out, for instance, cardiovascular exercises which are away to advance a sound life in an individual while meanwhile ensuring that they individual finds the opportunity to finish their own destinations. An instance of a health guide is Ryan C. Hurst who is an outstanding health guide and the kindred supporter of GMB wellbeing who offers health sharpening organizations to various clients, however utilizing the organizations of a health tutor is respected to have a few favorable circumstances to the individual in that they help an individual accomplish their health goals in that they will help the client accomplish their health destinations while meanwhile inducing the client not to surrender their targets. The other advantage of hiring a fitness coach is that they offer effective workout techniques which will help the client reach their goals for example if an individual wants to shed off some weight then the fitness coach is the right individual to help in this journey this is because they will select the best and effective exercises which will ensure that the individual sheds off weight but at the same time also give advice on the best diet which the individual can adapt so as to lose weight. A fitness coach also ensures supervision of the client who is working out this is because some of the equipment’s used can be very dangerous to the individual especially if they do not know how to use the equipment’s hence the fitness trainer ensures supervision so as to avoid injuries and also straining of various body parts.
Tips Tips for The Average Joe
The other advantage of working with a fitness coach is they offer special needs training to clients who have diseases such as asthma or a heart disease this is because they are trained on how to handle such cases and they can also be able to give advice on the beat form of training that the individual can engage in without putting the individual at a risk of suffering from an attack or making their condition more worse.
A Quick History of Exercises
The other benefit of hiring a fitness coach is that they offer individualized instructions and this means that an individual is able to have a one on one session with the fitness coach as opposed to visiting a gym which is usually packed with people and very few instructors, hence having a fitness coach ensures that the individual gets full attention of the fitness coach and this in turn increases the productivity of the individual.
Why Opt To Buy From An Online Canadian Pharmacy It was over the past years that the online pharmacies have increased. It is because of the fact that online pharmacies have a far-reaching market that it has also been growing in popularity. Providing a lot of benefits to its clients is the Canadian online pharmacy. There are many clients that love them because of these reasons. It is common for most patients to not let their identity be known . But the problem is that traditional pharmacies are all out in the open. But when it comes to the online pharmacies, they operate online making the whole process discreet and the patient will just receive the medicines on their doorsteps. It is the online pharmacy that will keep records of the patient that has bought medicines from them on their database. But this information are kept from public view and is maintained confidentially. There is a much lower price when you will buy medicines from a Canadian online pharmacy. The medicines that are being sold in Canada must adhere to the strict price regulation that the government has imposed. Because of the fact that the Canadian dollar is much lower, the medicines that they have are also priced low as well. That is why there are more people that prefer to buy medicines from them as they are lower in price but with the same quality.
If You Think You Understand Medicines, Then This Might Change Your Mind
For most people, they would want experience convenience when buying medicines and that is what the Canadian pharmacies are offering. It is the Canadian pharmacies that have a strong technical infrastructure which means that ordering medicines online will be very easy. The moment that the orders are made, they are immediately shipped to the client so that it will reach them in time. Credit card payment and other online payment are being accepted by Canadian online pharmacy.
If You Think You Understand Medicines, Then This Might Change Your Mind
The Canadian online pharmacy also do have a wide variety of drugs that they deal. It is them that you will be able to purchase a number of different medicine. It is the online pharmacy that will also be providing an index so that you will be able to scan the medicine of your choice and make an order. If it is a superior consultation and support service us what you are after, a Canadian online pharmacy will also be able to give that to you. If you have different questions regarding the drugs that you want to buy, you will get answers as they also have trained personnel to make sure that happens. The Canadian online pharmacies will also check the possible drug interaction that you will have if you will buy multiple drugs. When you take multiple drugs together, there is a possibility that you will experience an interaction which can be dangerous.
Critical Tools That People Can Invest In To Improve Their Overall Fitness Goals
There are a large number of people today that want to take their health to the next level, it is a great idea to invest on a number of health and fitness based tools that they can use on a daily basis to improve their health. There are a number of products that people can buy and start to use that will, without question would help take their fitness and nutrition level to go up and also get improve an easily live a healthy life. There are a number of the best health boosting equipment and tools which people must get to consider that are on the market so that they can make sure that they can invest on the right ones to help them live a healthy life.
The first one is a fitness trackers, this is a great tool where people would get to wear them on their body as they move around throughout the course of the day and would get to show them important data of the activities which they does for the day. They can easily get to see how many steps which have taken, how many calories they have burned and also get to show them data on how well they are doing in getting to improve their total health and fitness.
People must also invest on a food scale, it is vital that people are weighing and measuring the foods which they are eating on a daily basis due to the fact it can assist them on the calories they eat. A food scale would help people take the guesswork out when having to lose fat due to the reason when they utilize one, they can get to know where they stand about their caloric intake in trying to eat these types of food.
The next important tool that people can try to invest in is the skin caliper, this type of tool is great for assessing the total body composition without them getting to use bathrooms scales because of the reason it does not show them real data. it would get to measure the lean muscle mass versus fat mass and it is that important for people to know the difference so that they can get to improve the data and also their health and fitness methods in improving their life.
There are different health and fitness tools that people can use in order for them to be sure in having to reach their health and fitness goals easily, they must get to look for the ones that are reliable and can be utilized on an everyday basis. People must get to do research on which one of these products are best for them to use, they must make sure that the ones they purchase are good and also reliable in monitoring their health.